Search on: IMMUNOSUPPRESSIVE AGENTS 
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Descriptor English:   Immunosuppressive Agents 
Descriptor Spanish:   Inmunosupresores 
Descriptor Portuguese:   Imunossupressores 
Synonyms English:   Agents, Immunosuppressive
Immunosuppressants  
Tree Number:   D27.505.696.477.656
Definition English:   Agents that suppress immune function by one of several mechanisms of action. Classical cytotoxic immunosuppressants act by inhibiting DNA synthesis. Others may act through activation of T-CELLS or by inhibiting the activation of HELPER CELLS. While immunosuppression has been brought about in the past primarily to prevent rejection of transplanted organs, new applications involving mediation of the effects of INTERLEUKINS and other CYTOKINES are emerging. 
See Related English:   Antilymphocyte Serum
Antirheumatic Agents
 
History Note English:   66(64) 
Allowable Qualifiers English:  
AD administration & dosage AE adverse effects
AG agonists AN analysis
AI antagonists & inhibitors BL blood
CF cerebrospinal fluid CS chemical synthesis
CH chemistry CL classification
EC economics HI history
IM immunology IP isolation & purification
ME metabolism PK pharmacokinetics
PD pharmacology PO poisoning
RE radiation effects ST standards
SD supply & distribution TU therapeutic use
TO toxicity UR urine
Record Number:   7344 
Unique Identifier:   D007166 

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